Imaging Mass Spectrometry Society

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IMSS II & OurCon VI Joint Meeting

November 11-14, 2018
Charleston, South Carolina, USA


Sunday, November 11, 2018

13:00 - 17:00


Location: Rita Liddy Hollings Science Center, College of Charleston, 58 Coming St, Charleston, SC 29424

The following complimentary workshops will be held concurrently.  Registration is required for attending workshops.  Space is limited.  To register for the workshop, click here.

Workshop 1: MSiReader

  - Led by Prof. David Muddiman

MSiReader is an open-source vendor-neutral software to view and perform data analysis of Mass Spectrometry Imaging (MSI) Data. This workshop will inform users on basic functions within the software, time savers when processing data, and advanced functions. MSiReader is community grown software so bring your needs to the Workshop as we will take that input in the final part of the Workshop.

Workshop 2: METASPACE

- Led by: Theodore Alexandrov

In the METASPACE workshop, we will explain the challenge and pitfalls of searching for metabolites in imaging mass spectrometry data. We will present how it can be done using METASPACE, an open-source cloud software. We will walk you through the bioinformatics methods behind METASPACE, give a step-by-step tutorial and a demo on how it can be used. We will show how the METASPACE community knowledge base of over 3000 datasets contributed by users can be searched, browsed, and used in your research.

Workshop 3: Imaging Mass Spectrometry of Glycan and Matrix Pathology

- Led by Prof. Richard R. Drake

- Speakers:  Kristina Schwarmborn, Peggi Angel, Jan Kobarg

 This lecture-focused workshop will include discussion on histological stains and imaging mass spectrometry approaches for N-glycans and extracellular matrix proteins. Hosted by the Medical University of South Carolina Proteomics Center.

18:00 - 21:00

Opening Gala

Location: Halsey Institute of Contemporary Art

Welcome and Opening Remarks

Steve Castellino, Ph.D.
President IMSS, Director Ex Vivo Imaging
Collegeville, PA, USA  

Keynote Lecture

Next Generation MALDI Imaging Mass Spectrometry: Enabling Molecular Microscopy in the New Age of Biology and Medicine

Dr. Richard M. Caprioli
Professor of Biochemistry
Director of the Mass Spectrometry Research Center
Vanderbilt University School of Medicine
Nashville, TN


Reception will be held in the Exhibition Hall after the Keynote Lecture.  Hors d’oeuvres and libations will be served.

Monday, November 12, 2018

07:00 - 08:00

Continental Breakfast

08:00 -08:10


Steve Castellino, Ph.D., President IMSS, Director Imaging MS and DMPK, GlaxoSmithKline, King of Prussia, PA, USA

Ron Heeren, Ph.D., President Mass Spectrometry Imaging Society, Professor and Division Head Imaging Mass Spectrometry, Maastricht Multimodal Molecular Imaging Institute, Maastricht, Netherlands

08:10 - 09:10

Plenary Session

From Data to Knowledge: Changing Medicine Discovery and Development One Image at a Time

Steve Castellino, Ph.D., President IMSS, Director Imaging MS and DMPK, GlaxoSmithKline, King of Prussia, PA, USA

Pushing the boundaries of translational imaging mass spectrometry

Ron Heeren, Ph.D., President Mass Spectrometry Imaging Society, Professor and Division Head Imaging Mass Spectrometry, Maastricht Multimodal Molecular Imaging Institute, Maastricht, Netherlands

09:10 - 11:50


Session chairs: 

Reid Groseclose, Ph.D., Fellow, Senior Investigator, GlaxoSmithKline, King of Prussia, PA, USA

Michael Becker, Ph.D., Head of MALDI Imaging MS, Development NCE DMPK, Boehringer Ingelheim , Pharma GmbH & Co. KG

09:10 - 10:00

Mass Spectrometry-Based Imaging at Merck: Enabling Rapid Tissue Distribution of Drugs and Metabolites in Drug Discovery and Development

Bingming Chen, PhD, Senior Scientist, PPDM ADME, Merck Research Laboratories, West Point, PA 

Amodiaquine Localization from the Whole-Body to the Liver Lobule

Kerri Grove, PhD, Investigator III Analytics and Imaging MS - Novartis Institutes for BioMedical Research, Emeryville, CA 

Visualizing ART with MSI: New Tools for Understanding HIV Pharmacology to Guide Treatment and Prevention

Eli Rosen, PhD, Research Associate Professor, Eshelman School of Pharmacy - University of North Carolina, Chapel Hill, NC 

10:10 - 10:25 Break

10:25 - 11:30

Investigating Drug-induced phospholipid changes in tissues by Mass Spectrometry Imaging

Michael Becker, PhD, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach a.d. Riss, Germany 

Method for quantification of target exposure and engagement using QMSI

Jonathan Stauber, PhD, CEO Imabiotech

Imaging mass cytometry and mass spectrometry imaging combined to define drug delivery, metabolism and response

Richard Goodwin, PhD, Principal Scientist, Head MS Imaging, Astra Zeneca, Cambridge, United Kingdom

11:30 - 11:50 FDA Perspective

The emerging role of MALDI IMS at the FDA: current and future implications for toxicological research.

Ellen Jones, Ph.D., Research Biologist, National Center for Toxicological Research, FDA Pine Bluff, AR USA

11:50 - 12:30

Lunch : South Carolina BBQ

12:30 - 13:30

Rapid Fire Oral Presentations

Session Chair

Erik Cressman, M.D., Ph.D, FSIR, Director John S. Dunn Center for Radiologic Sciences, Department of Interventional Radiology, MS Anderson Cancer Center, Houston TX, USA

13:30 - 15:30


Session Chairs:

Chris Anderton, Ph.D., Scientist, Pacific Northwest Laboratory, Richland, WA, USA

Shane Ellis, Ph.D., Assistant Professor, Maastricht Multimodal Molecular Imaging Institute, Maastricht, Netherlands

New Advances in IR-MALDESI for Mass Spectrometry Imaging

David C. Muddiman, PhD, Jacob and Betty Belin Distinguished Professor, Director, Molecular Education, Technology, and Research Innovation Center (METRIC), North Carolina State University, Raleigh, North Carolina, USA

Pushing the limits of spatial resolution in MALDI-MSI – Transmission-Mode MALDI with Laser Postionization allows for a pixel size below 1 µm

Marcel Niehaus1; Mikhail Belov2; Klaus Dreisewerd1,3 Jens Soltwisch*1,3

1: Institute for Hygiene, University of Münster, Germany

2: Spectroglyph LLC, Kennewick, Washington, United States

3: Interdisciplinary Centre for Clinical Research, University of Münster, Germany

High Performance MALDI Mass Spectrometry Imaging by 21 tesla FT-ICR MS

Donald. F. Smith, PhD, National High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida, USA

Coupling LESA to Structures for Lossless Ion Manipulations: Revealing the Spatial Profile of Disaccharides in a Simulated Peatland Ecosystem

Dušan Veličković, PhD, Postdoctoral Associate, Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington

Next-Gen Instrumentation for 3D Mass Spectrometry (Surface) Imaging

Facundo M. Fernandez, PhD, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA

Latest Developments in Cluster Beam Technology for SIMS: Towards Greater Spatial Resolution, Ion Yields, and Etch Rates!

Allen Bellew, PhD, Ionoptika Ltd, Millbrook, UK

15:30 - 15:50

Gold Sponsor Science Talk: Waters

SONAR DESI imaging: a novel method to image precursors and fragments for molecular identification in a single experiment

Mark Towers (Senior scientist), Emmanuelle Claude (Principal scientist), Waters Corporation, Wilmslow, UK

15:50 - 16:10


16:10 - 18:10

Young Guns

Session Chairs:

Bram Heijs, Ph.D., Head Mass Spectrometry Imaging Group, Center for Proteomics and Metabolomics, Leids Universitair Medisch Centrum, Leiden, Netherlands

Heath Patterson, Ph.D., Postdoctoral Research Fellow, Department of Biochemistry, Vanderbilt University, Nashville, TN, USA

MALDI-MS imaging of lipid C=C positional isomers enabled by on-tissue Paternò-Büchi photo-derivatization

Antonín Bednařík, PhD, Postdoctoral Fellow, Klaus Dreisewerd Laboratory, University of Münster, Germany

Non-Enzymatic Digestion of Proteins for Imaging Mass Spectrometry

Andrew Goodenough, PhD Student, Franco Basile Laboratory, University of Wyoming, Laramie, WY, USA

Optimization of DESI-MS Imaging of Proteins Directly from Biological Tissue Sections

Kyana Garza, PhD student; Livia Eberlin Lab, University of Texas at Austin, Austin TX

Glycan and Lipid MALDI IMS integrated with genomic and metabolomic defined clinical breast cancer cohort

Danielle Scott, PhD Candidate, Richard Drake Laboratory, Medical University of South Carolina, Charleston, SC, USA

Desorption and ionisation in UV-MALDI MSI

Kenneth Robinson, PhD Candidate, Josephine Bunch Laboratory, National Physical Laboratory, UK

Increasing ionization and desorption efficiency of neutral lipids from thin tissue sections for high spatial resolution MALDI IMS

Martin Dufresne, PhD, Postdoctoral Fellow, Richard Caprioli Laboratory, Vanderbilt University, Nashville, TN, USA

18:10 - 18:30

Gold Sponsor Science Talk : NRL

Unlocking Clinical Insights through Histology Guided Mass Spectrometry Profiling

Erin H. Seeley, Ph.D., Chief Technology Officer, New River Labs, LLC

18:30 - 20:00


Cocktails Sponsored by Bruker and NRL

20:00 -

Enjoy Charleston

Tuesday, November 13, 2018


Inaugural Fun Run/Walk Sponsored by HTX

Depart from and return to Francis Marion Hotel (387 King Street)

07:00 - 08:00

Full Breakfast: « Georgestreet Pancake Station » at the Gaillard Center

08:00 - 09:00

Plenary Session


Nathalie Agar, Ph.D., Associate Professor, Harvard Medical School and Brigham and Women’s Hospital, Boston MA USA

Mapping of brain neurotransmitter networks by reactive MALDI-MSI

Per Andren, Ph.D., Professor, Department of Pharmaceutical Biosciences, Uppsala Universitet, Uppsala, Sweden

09:00 - 11:40

From the Clinic

Session Chairs:

Kristina Schwamborn, M.D., Ph.D., Consultant, Institute of Pathology, TU Munich, Germany

Alison Scott, Ph.D., Research Associate Professor, Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD USA

9:00 - 10:00

MALDI-MSI – Applications in Pathology 

Kristina Schwamborn, MD, PhD, Consultant, Institute of Pathology, TU Munich, Germany

MALDI-MSI steps into the pathology lab: benefits and challenges 

Rita Casadonte, PhD, Group Leader, Proteopath GmbH, Trier, Germany

Ambient ionization for fresh and frozen analysis of tumor specimens 

Tiffany Porta, PhD, Assistant Professor at the Maastricht MultiModal Molecular Imaging Institute

10:00 - 10:15 Break

10:15 - 11:20

Stromal signatures of breast cancer 

Peggi Angel, PhD, Assistant Professor, Department of Cell and Molecular Pharmacology & Experimental Therapeutics, Medical University of South Carolina, Charleston, SC USA

Spatial metabolomics for kidney precision medicine 

Guanshi Zhang, PhD, Assistant Professor/Research, Center for Renal Precision Medicine, Department of Medicine, The Univesity of Texas Health San Antonio, Texas, USA

Imaging mass spectrometry reveals chemical signaling in cancer primary metastases 

Laura Sanchez, PhD, Assistant Professor, Department of Cell and Molecular Pharmacology & Experimental Therapeutics, University of Illinois at Chicago, Chicago, IL USA

11:20 - 11:40

Gold Sponsor Science Talk: HTX Technologies

Beyond spraying: SepQuant(TM) surface analysis and Sublimator(TM) nano-coating

Alain Creissen, Imaging Product Manager, HTX Technologies, LLC Chapel Hill, NC USA

11:40 - 12:25

Posters & Snacks

12:25 - 14:25


Session Chairs:

Raf Van der Plas, Ph.D., Assistant Professor, Delft University of Technology, Delft, Netherlands & Vanderbilt University Mass Spectrometry Research Center, Nashville, TN, USA

Kylie Bemis, Ph.D., Postdoctoral Future Faculty Fellow, College of Computer and Information, Northeastern University, Boston, MA, USA

Detecting differentially abundant ions in MSI experiments with complex designs using Cardinal

Dan Guo, PhD Student, Northeastern University, Boston, MA USA

Correlation methods for untargeted image analysis with MSiReader

Ken Garrard, Senior Research Scholar, North Carolina State University, Raleigh, NC USA

Advanced Registration of MALDI Imaging Mass Spectrometry and Microscopy through Autofluorescence Microscopy

Heath Patterson, PhD, Research Instructor, Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN USA

Novel methods to address computational challenges in multi-site, multi-scale imaging experiments

Alex Dexter, PhD, Postdoctoral Fellow, Laboratory of Prof. Josephine Bunch, National Physical Laboratory, Teddington, Middlesex TW11 0LW, UK

METASPACE as an open AI platform for metabolomics discoveries

Theodore Alexandrov, PhD Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany

How to make the most out of your data: new and improved tools for the community

Alan Race, PhD student, Laboratory of Andreas Römpp, Bioanalytical Sciences and Food Analysis, University of Bayreuth, Germany

14:25 - 14:45

Gold Sponsor Science Talk: Shimadzu

IMAGEREVEAL a New Solution for Imaging Mass Spectrometry Data Analysis
Ryan Walsh Ph.D., Shimadzu Scientific Instruments, Columbia, MD USA


Tradesmen’s Brewery

Wednesday, November 14, 2018

07:00 - 08:00

Continental Breakfast

08:00 - 09:00

Plenary Session

MS Imaging of Proteins from ex-vivo to in-vivo: Beyond Next Generation Immunohistochemistry

Professor Isabelle Fournier, Ph.D., University of Lille, France.

Title: TBD

Kevin Schey, Ph.D., Professor of Biochemistry, Professor of Ophthalmology and Visual Sciences, Vanderbilt University, Nashville, TN USA.

09:00 - 11:20

Method Development

Session Chairs:

Pierre Chaurand M.D., Ph.D., Professor, Department of Chemistry, Universite de Montreal, Montreal, Canada

Martina Marchetti-Deschmann, Ph.D., Associate Professor, Vienna University of Technology, Institute of Chemical Technologies and Analytics, Vienna, Austria

09:00 - 10:00

Analyzing lipids from Drosophila Malpighian tubule by imaging mass spectrometry

Ethan Yang, PhD student; Pierre Chaurand Lab, Université de Montréal, Montréal, CA

Towards visualizing microbial community dynamics and metabolic activity within soil microbiomes using microscopy and MSI

Arunima Bhattacharjee, PhD, Postdoctoral Research Associate, Pacific Northwest National Laboratory (PNNL), Richland, WA, USA

Differentiation of lipid isomers by desorption electrospray ionization mass spectrometry imaging coupled to ultraviolet photodissociation

Clara Feider, PhD student; Laboratory of Livia Eberlin, University of Texas at Austin, Austin TX, USA

10:00 - 10:20 Break

10:20 - 11:20

The benefits of elemental and molecular imaging from one tissue section – from chicken toes to Si particles in lung tissue

Martina Marchetti-Deschmann, PhD, Associate Professor, TU Wien; Institute of Chemical Technologies and Analytics, Mass Spectrometric Bio- and Polymer Analysis, Vienna, Austria

Mapping the distribution of neuropeptides through mass spectrometry imaging

Heather Hulme, PhD, Postdoctoral Fellow, Medical Mass Spectrometry Imaging, National Resource for Mass Spectrometry Imaging, Science for Life Laboratory, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden

High resolution mapping of microbes and metabolites exposes a network of beneficial metabolic interactions

Manuel Liebeke, PhD, Max Planck Institute for Marine Microbiology, Department of Symbiose, Metabolic Interactions, Celsiusstr., Bremen Germany

11:20 - 11:40

Gold Sponsor Science Talk: Bruker

New Developments for MALDI Imaging

Shannon Cornett, Ph.D., Imaging, Buisness Manager, Bruker

11:40 - 13:20

Lowcountry Lunch at the Gaillard Center


13:20 - 15:20


Session Chairs: 

Lisa Cazares, Ph.D., Principal Investigator for the Geneva Foundation, U.S. Army Medical Research Institute of Infectious Disease, Fort Detrick, MD, USA

Andreas Rȍempp, Ph.D., Professor, Chair of Bioanalytical Sciences and Food Analysis, University of Bayreuth, Germany

MALDI FT-ICR imaging for the investigation of the metabolomic response to viral infection, bacterial infection and toxin exposure

Lisa Cazares, PhD, Principal Investigator for the Geneva Foundation, USAMRIID: Molecular and Translational Sciences: Fort Detrick, MD, USA

MALDI MS Imaging Reveals Temporal and Spatial Dynamics of Bioactive Lipids in the Development of Restenosis

Jillian Johnson, PhD Student, Lingjun Li’s Laboratory, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA

Molecular mapping of microbial communities at the host-pathogen interface by multimodal imaging mass spectrometry

Jeffrey Spraggins, PhD, Research Assistant Professor, Dept. of Chemistry, Vanderbilt University, Nashville, TN, USA

Tracing intracellular parasite infections in animal tissue in 3D with phase-contrast synchrotron radiation micro-computed tomography to guide spatial metabolomics

Benedikt Geier, Ph.D. student, Max-Planck-Institut für Marine Mikrobiologie Celsiusstr. 1 D-28359 Bremen, Gerrmany

SIMS and MALDI; complimentary, complementary or competition…

John Fletcher, Ph.D., Senior Lecturer, Department of Chemistry and Molecular Biology, U Gothenburg, Sweden

How do we (as a community) identify proteins in on-tissue digestion experiments?

Andreas Rȍempp, PhD, Professor, Chair of Bioanalytical Sciences and Food Analysis, University of Bayreuth, Germany

15:20 - 15:40

Gold Sponsor Science Talk: N-Zyme

Glycan analysis from tissue to serum - identification and validation of a biomarker for the early detection of hepatocellular carcinoma

Anand Mehta, Ph.D. , Chief Knowledge Officer, N-Zyme, LLC

15:40 - 15:50


15:50 - 17:00

The Future of Imaging MS Science

Session Chairs

Liam McDonnell, Ph.D., Professor, Proteomics Group Leader, Fondazione Pisana per la Scienza, Pisa, Italy

Richard R. Drake, Ph.D., Professor, Director Medical University of South Carolina Proteomics Center, Charleston, SC USA

Top-down microproteomics bridged to MALDI MS imaging reveals the molecular physiome of brain regions

Michel Salzet, Distinguished Professor in Immunology, Laboratoire PRISM U1192 Inserm, Bâtiment SN3, 1er étage, Université de Lille, 59650 Villeneuve d'Ascq

Novel IMS tools for Probing Alzheimer Disease Pathology

Jörg Hanrieder, Associate Professor, Hon. Sen. Res Assoc., Dept. Psychiatry and Neurochemistry, Sahlgrenka Academy at Gothenburg University,  Mölndal Hospital, Hus V3, 43180 Mölndal, Sweden, Dept. Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, WC1N 3BG Queen Square, London, UK

From a novelty to a core technology: IMS in the future of drug discovery and development

Reid Groseclose, Ph.D., Fellow, Senior Investigator, GlaxoSmithKline, Collegeville, PA, USA

17:00 -17:15

Closing Remarks

Steve Castellino, Ph.D., President IMSS, Director Imaging MS and DMPK, GlaxoSmithKline, King of Prussia, PA, USA








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