Drug Metabolism and Distribution group within the DMPK department of Abbvie utilizes MS imaging to help drive molecules to the market. The successful candidate will pursue several research initiatives that will enhance the utility of MSI for tissue distribution and understanding of safety.  One area is to increase the sensitivity of imaging by utilizing novel ion source and targeted imaging methodologies to allow projects to be investigated when analytes fall below the current limit of detection. It is also important to Identify endogenous markers in various tissues (eye, liver, kidney, heart, etc.) to provide a high confidence of assignment in tissue distribution analysis. The generation of ion atlas will broadly improve spatial specificity, accelerate biomarker discovery for drug development, and significantly increase the ability to fully investigate the molecular drivers of biological processes. In addition, large molecule imaging methods and improved protocols need to be developed for MS imaging to be more robust and routine. This would permit the distribution of ADCs, antibody, and anticancer agents to be more fully investigated by MS imaging spectrometry.

please apply the position through Abbvie's site:

https://careers.abbvie.com/abbvie/jobs/2100676?lang=en-us&previousLocale=en-US

The new Mass Spectrometry Imaging Facility at the University of Texas at Austin seeks a postdoctoral fellow. The position will involve working with facility collaborators and clients for the design and execution of mass spectrometry imaging projects with a focus on cancer research applications.  A major focus of the position will be the development and integration of UV photodissociation with MS Imaging.  The position will also involve the development of new methods for analyte detection, both through sample preparation and instrumental tuning and modification.  The successful candidate should be able to work efficiently on multiple projects with multiple collaborators and have excellent verbal and written communication skills.

A PhD in Analytical Chemistry or a related scientific field with an emphasis in mass spectrometry is required.  The ideal candidate will have instrumentation development experience and some familiarity with lasers.  Prior experience with biological samples (tissue/biofluids), and especially imaging, is preferred.  Experience with statistical analysis of mass spectrometry data is a plus.

The Mass Spectrometry Imaging Facility is a fast-paced lab, exploring numerous clinical and preclinical studies.  The facility offers both MALDI and DESI imaging of all types of molecules ranging from small metabolites to intact proteins.  The facility works with both fresh frozen and FFPE tissue so the successful candidate will have exposure to a wide variety of sample preparation and analysis techniques.  Projects within the facility are research-focused and will allow the opportunity for critical thinking and problem solving in order to produce top quality data.

Interested candidates can contact Erin Seeley     erin.seeley@utexas.edu

Facility Website:  https://sites.cns.utexas.edu/mass-spec-imaging

Investigator, MALDI MS Bioimaging (myworkdayjobs.com)

We have an exciting new position available within the MALDI MS Bioimaging group at GSK, based from our world-class R&D site at Collegeville, PA.  The role will focus on development of non-targeted imaging mass spectrometry-based workflows to deliver functional pharmacology mechanistic endpoints to projects.  As part of the MALDI MS Bioimaging team, you’ll be responsible for the application and advancement of imaging mass spectrometry (IMS) to better understand the mechanisms of drug tissue disposition, pharmacokinetics, pharmacology, and toxicology in the development of safe and efficacious drugs.  Utilizing leading edge MS instrumentation, custom imaging software tools, and pioneering IMS tissue quantification, our innovative group works collaboratively to help drive critical decisions in all therapeutic areas. 

Bioimaging at GSK

The Bioimaging department brings together key areas of in vivo and ex vivo imaging combined with histology to understand both disease state and intervention, combining data on drug distribution with the effect that distribution has on intact biological systems.  At GSK we believe that the fewer barriers there are in delivering the science, then the better our delivery of new medicines to patients. As part of the wider In Vitro/In Vivo Translation platform we encourage enterprise collaboration as well as external partnership with the wider scientific community to achieve our full potential.

Key Responsibilities:

• Develop non-targeted IMS workflows to deliver functional pharmacology mechanistic endpoints for projects and enhance understanding of biological systems

• Develop molecular identification strategies using tissue extracts and tissue surface analysis methods (e.g. LESA) to achieve accurate molecular assignment from MALDI imaging data

• Work in partnership with the Imaging Analytics teams and other stakeholders to build data repositories and custom pipelines to achieve streamlined identification of endogenous biological molecules and cellular pathways, and facilitate broader data reuse

• Work in partnership with project teams to understand project issues, provide input and report data to matrix teams, including close networking with all imaging groups across GSK.

• Maintain timely communication to named key study personnel, other key stakeholders and management, of study related events and/or deviations.

• Share responsibility for lab management, equipment maintenance, safety rep and similar roles.

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• PhD in Chemistry, Biology, Physical Sciences, or related discipline.

• Experience in mass spectrometry-based metabolomics and/or lipidomics data acquisition and analysis

• Familiarity and experience with common identification strategies for endogenous biological molecules

• Experience with troubleshooting and maintaining complex instrumentation

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• Expertise in imaging mass spectrometry

• Experience with Thermo or Bruker mass spectrometers

• Evidence of effective, collaborative interpersonal, organizational and communication skills, both oral and written, for working in a multi-disciplinary scientific team environment.

Why GSK?

Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:

• Operating at pace and agile decision-making – using evidence and applying judgement to balance pace, rigour and risk.

• Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.

• Continuously looking for opportunities to learn, build skills and share learning.

• Sustaining energy and well-being

• Building strong relationships and collaboration, honest and open conversations.

• Budgeting and cost-consciousness

*LI-GSK

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