We have an opening for a Lead Researcher in the Department of Chemical Biology and Therapeutics at St. Jude Children's Research Hospital

A successful applicant for this position will be able to fulfill one of two roles outlined below:

·       Seek to advance the application of imaging mass spectrometry (IMS) to contextualize drugs and endogenous metabolites in pre-clinical tissues.

or

·       Apply a background in label-free MS assay development, evidenced by prior scientific contributions, in drug discovery projects.

As a member of the St. Jude Chemistry Centers, the successful applicant will have access to a skilled team of chemists who will collaborate and build small molecules inspired by discoveries or applications developed through either role. Demonstrated ability to independently optimize associated analytical or biochemical procedures is a requisite skill for either.

Readily available equipment includes state-of-the-art mass spectrometers (7.0 Tesla FTICR, timsTOF, QToF, QQQ), many of which are or can be coupled with micro or analytical flow UPLC. In addition, our group has implemented Echo acoustic dispensing for MALDI-MS assays so familiarity with this technology is preferred.

Workflows have already been established for the analysis of drug in tissues by MALDI imaging mass spectrometry and continue to be enhanced by leveraging the highly diverse imaging modalities on the St. Jude campus.  Advanced sample treatments such as on-tissue enzyme digestion methods, mass-tagged immunohistochemistry (MALDI-IHC) or discovery of new matrices will be encouraged. A successful applicant for this role will be working directly with St. Jude investigators to assess the need and feasibility of applying IMS to pre-clinical studies of tumors.

Workflows have also been established for label-free screening of St. Jude’s chemical libraries. There is particular interest in leveraging an ion mobility analyzer to demarcate mixtures of isobaric or isomeric molecules within a high throughput screening context.

A wide array of other automation and analytical technologies are made available as part of a highly diverse and collaborative environment. This position is expected to exert a high level strategic and practical impact on the research within the department of Chemical Biology & Therapeutics and translation across the hospital.  Assistance in other areas of activities such as SOP-writing, record keeping, reporting, and preparation of data specifically for manuscripts is expected occasionally.

Apply Here

Job Description:

AmberGen seeks an experienced, energetic, highly motivated and creative scientist to join an expanding biotech company developing cutting edge technology in the field of spatial biology and mass spectrometric imaging. A successful candidate will have an opportunity to play a key role in the development and commercialization of pioneering mass spectrometric tissue imaging technology.

 

Responsibilities:

• Report directly to the Chief Scientific Officer; work with other science team members on development of AmberGen’s Mass Spectrometric tissue imaging technology and applications in clinical pathology/oncology.
• Conduct experiments on advanced MSI instrumentation including Bruker timsTOF
• Present research at conferences, co-author papers and develop grant proposals
• Work directly with customers on their application needs 

Qualifications:

• Graduate and/or post-doctoral experience in mass spectrometric imaging,
• Additional relevant areas of experience sought include immunohistochemistry (IHC), other tissue imaging modalities including fluoresence, Raman and FTIR, biochemistry and histopathology.
• Strong organizational abilities, meticulous laboratory skills, ability to work as part of a team,
• Compatibility with a small business environment including early-stage R&D, creativity and the ability to quickly adapt to new projects.
• Good communication skills

 

How to Apply:

The position is available immediately. AmberGen is an innovative and growing company which offers competitive benefits, an exciting work environment and an attractive location in the Greater Boston Area. Job responsibilities and salary will be commensurate with the applicant’s experience and skill level. AmberGen is an equal opportunity employer.

 

Please apply through the Online interface or send your résumé or CV (PDF preferred) to info@ambergen.com using “2022 MSI Scientist” in the Subject line.

 

For more information, please contact:

 

John Gillespie

CEO

info@ambergen.com

 

 

About AmberGen, Inc.:      AmberGen, Inc. is a privately held, Boston-area company founded in 1995 to commercialize pioneering photonic technology developed at Boston University’s Molecular Biophysics Laboratory and the Photonics Center. AmberGen’s development of proprietary peptide code photocleavable linkers (PC-Linker™) led to the early introduction of novel photocleavable reagents, such as PC-Biotin and PC-Phosphoramidites which underlie several major commercial proteomic and genomic technologies. The company’s mission is to innovate in the area of therapeutics and diagnostics by solving key problems that limit progress in medicine. AmberGen’s approach combines patented techniques in proteomics and light-based control of biomolecules.   For more information, see www.ambergen.com.

Investigator, Bioimaging (Collegeville, PA) (myworkdayjobs.com)

We have an exciting new position available within the Bioimaging team at GSK, based at our world-class R&D site in Collegeville, PA.  The role will focus on development of targeted and non-targeted optical and mass spectrometry-based imaging workflows to advance our project decision making based on spatial drug distribution and functional pharmacology mechanistic endpoints.  As part of the Bioimaging team, you’ll be responsible for the application and advancement of imaging mass spectrometry (IMS) to better understand the mechanisms of drug tissue disposition, pharmacokinetics, pharmacology, and toxicology in the development of safe and efficacious drugs.  Utilizing leading edge MS instrumentation, custom imaging software tools, and pioneering IMS tissue quantification, our innovative group works collaboratively to help drive critical decisions supporting the advancement of novel medicines.  Building on the established spatial drug distribution workflow, complementary imaging approaches are being applied to define the detailed tissue architectures and cellular microenvironments to contextualize the pharmacological outcome.  The successful candidate will join a highly collaborative and motivated team of scientists focused on providing innovative solutions to help deliver safe and efficacious new medicines to patients.

Bioimaging at GSK

The Bioimaging department brings together key areas of in vivo and ex vivo imaging combined with histology to understand both disease state and intervention, combining data on drug distribution with the effect that distribution has on intact biological systems.  At GSK we believe that the fewer barriers there are in delivering the science, then the better our delivery of new medicines to patients. As part of the wider In Vitro/In Vivo Translation platform we encourage enterprise collaboration as well as external partnership with the wider scientific community to achieve our full potential.

Key Responsibilities:

• Responsible for the design, facilitation, and delivery of targeted and non-targeted MALDI IMS experiments including preparation, acquisition and data analysis to support multiple programs.
• Responsible for generating and integrating spatial omics data to measure spatial biology, contextualize drug distribution, and discover pharmacodynamic biomarkers
• Work together with matrix teams to propose and deliver potential solutions to key project issues including networking with other groups across GSK.

• Effectively analyze and interpret IMS data for presentation to project teams.
• Through collaboration with imaging and non-imaging colleagues, integrate IMS data with other methodologies as part of a multi-modal approach to drive critical project decisions.
• Further the development of both quantitative and non-targeted IMS workflows to improve upon the impact and efficiency of acquisition and data processing strategies.
• Support the upkeep and maintenance of lab instrumentation.

Basic qualifications:

• PhD in Chemistry, Biology, Physical Sciences, or related discipline with a focus on the drug-discovery process.
• Experience with generating spatial transcriptomics, proteomics, and/or metabolomics data.
• Experience with troubleshooting and maintaining complex instrumentation.
• Knowledge of visualization, statistics, and bioinformatic strategies.
• Established track record of continued scientific contributions through presentations and publications.

Preferred Qualifications:

• Hands-on experience with Bruker mass spectrometers including Solarix/SciMax and Rapiflex systems.
• Evidence of effective, collaborative interpersonal, organizational and communication skills, both oral and written, for working in a multi-disciplinary scientific team environment.

Apply

Link to job posting:

Investigator, Bioimaging (Collegeville, PA) (myworkdayjobs.com)

Senior Technologist - High Resolution Mass Spectrometry

Job description: Under the guidance of the Lead Technologist, the Senior Technologist will apply their specialist technical knowledge and skills to assist academic staff, students and other stakeholders access the analytical platforms, primarily ESI/MALDI High resolution–Mass spectrometry, available in the Science Faculty’s Mass Spectrometry Facility.

Specialist Portfolio: Mass Spectrometry Facility

• Provide management and oversight of the Bruker solariX XR high-resolution ESI/MALDI FT-ICR mass spectrometer 

• Provide specialist training and advice to users, supporting the collection, interpretation, and management of complex data

• Provide expert input into research project planning

• Develop or adapt as required, sample preparation protocols, mass spectrometry methods and data analysis workflows

• Identify and implement relevant new techniques, workflows, and software packages

• Post-graduate research qualification in Biochemistry, Chemistry, Biology, Life Sciences or in a relevant field, and/or equivalent experience

• Experience: 4 to 5 years (post-graduation) including 1 to 2 years demonstrated experience in FT-MS analysis, in proteomics, MS-imaging, metabolomics or similar fields.

• FT-MS instrument maintenance, biological mass spectrometry, mass spectrometry data analysis, sample preparation techniques

• General laboratory skills (use of pipettes, centrifuges, balances etc)

• Intermediate Microsoft Office skills (Word, Excel and PowerPoint)

• Ability to effectively communicate complex mass spectrometry concepts and results to a broad community of users

The University of Auckland is New Zealand’s leading university and maintains significant computational, laboratory and analytic facilities. Auckland itself is frequently rated as one of the world’s most liveable cities. 

• Flexible employment practices (including working from home, flexible hours)

• Up to 6.75% company superannuation scheme

• A competitive salary with five weeks’ annual leave

Job description: Under the guidance of the Lead Technologist, the Senior Technologist will apply their specialist technical knowledge and skills to assist academic staff, students and other stakeholders access the analytical platforms, primarily ESI/MALDI High resolution–Mass spectrometry, available in the Science Faculty’s Mass Spectrometry Facility.

Knowledge and Skills

This position is a 36 month fixed term, fulltime role.

For more detailed information, please refer to the Position Description

Mō tō mātou rōpū | About the team

The Faculty of Science’s Technical Services Team comprises over 100 technical staff providing specialist support to the Faculty’s academic staff and students across 9 of the 10 Departments. They contribute technical knowledge and expertise to research and teaching activities while ensuring the ongoing operation and compliance of a vast range of laboratories, workshops, teaching facilities, research equipment, vehicles, and boats.

The Life Sciences Mass Spectrometry Platform (LSMS) is a cross-faculty initiative hosted by the Faculty of Science, Faculty of Medical and Health Sciences, and the Liggins Institute to promote access to cutting-edge mass spectrometry services and data analysis relevant to Life Sciences research. One component of the LSMS Platform is the Mass Spectrometry platform hosted in the Faculty of Science Shared Research Equipment programme.

The niche team are made up of specialist professionals and academics who work closely together on site.

Ngā āhuatanga kei a mātou | What we offer

The University is committed to providing an excellent working environment through:

In addition, we also offer career development programmes, discounted car parking, a generous parental leave allowance, childcare, and a number of other discounts on internal and external services. 

For more information, please visit Staff Benefits

Me pēhea te tuku tono | How to apply

Applications must be submitted online, by the closing date of 23 April 2022 to be considered. Please include your cover letter and your CV highlighting how you can meet the skills and experiences detailed above.

Please reach out to Martin Middleditch, Lead Technologist (Mass Spectometry) m.middleditch@auckland.ac.nz for a confidential conversation. Please note we are happy to answer your questions, but we do not accept applications by email.

Additional Information

Covid-19 Vaccination

The University of Auckland is committed to protecting the health, safety and well-being of our staff and students. All students, staff and visitors need to be fully vaccinated against Covid-19, or medically exempt, in order to come onto our campuses or to take part in face-to-face University-managed activities. Therefore, we are only able to consider applicants who are fully vaccinated against Covid-19 or have a New Zealand Ministry of Health issued medical exemption and evidence of this will be requested as part of your employment. You can read more about the University’s vaccination policy here.

Equity

The University is committed to meeting its obligations under the Treaty of Waitangi and achieving equity outcomes for staff and students in a safe, inclusive and equitable environment.  For further information on services for Māori, Pacific, women, LGBTQITakatāpui+, people with disabilities, parenting support, flexible work and other equity issues go to www.equity.auckland.ac.nz 

I'm interested

https://www.smartrecruiters.com/TheUniversityOfAuckland/743999814796456-senior-technologist-high-resolution-mass-spectrometry

School of Pharmacy, University of Southern California is seeking a core manager for mass spectrometry core.

The core manager will oversee and supervise day-to-day operations of a facility that broadly applies to metabolomics, lipidomics, proteomics, and MALDI imaging approaches to support basic, translational and clinical research in cancer, chronic inflammatory conditions, infectious diseases, neuroscience and pharmacological and biomarker development efforts. 

For detailed job description and apply: https://usccareers.usc.edu/job/los-angeles/core-manager-mass-spectrometry-core-facility/1209/19361658848.

Contact: 
Delisha Meishery-Patel, Ph.D.
delishap@usc.edu

Boehringer Ingelheim is currently seeking a Mass Spectrometry (Postdoctoral Associate) for program development to join the Material and Analytical Sciences department located at our Ridgefield, CT. facility.

As an employee, you will actively contribute to the design, development and implementation of novel Mass Spectrometry prediction programs for evaluating and advancing BI products. Our global presence provides opportunity to collaborate internationally, offering visibility and the potential to directly contribute to the company's success. We realize that our strength and competitive advantage lie with our people. We support our employees and foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees.

Duties and Responsibilities:

• Compile and analyze data of small organic molecules using Mass Spectrometry,
• Interpret EI, APCI and ESI MS and MS/MS fragmentation spectra.
• Mass Spectrometry identification of trace levels of small organic molecules that may result from process impurities, degradation products, or metabolites.
• Design and train neural networks to model components from Mass Spectrometry data.  This will involve curating training sets from experimental data.
• Assist in data collection and processing of Mass Spectrometry data as required.
• Document and manage code developed using standard source control methods.
• Research methods to scale training and use of neural networks on multiple nodes in high performance computing environments.
• Develop, document and maintain new and existing MS prediction software.
• Write protocols, methods and technical reports; provide scientific interpretation of results and maintain a detailed record of work performed.
• Contributing author to original manuscripts, posters and presentations; able to present work at external and internal scientific meetings.
• Independently solve complex problems with minimal assistance.

Required Education & Experience:

• Ph.D. in Analytical / Mass Spectrometry with strong background in Artificial Intelligence or similar area of study.

Eligibility Requirements:

• Must be legally authorized to work in the United States
• Must be willing to submit to a background investigation, including verification of your past employment, criminal history, and educational background
• Must be willing to take a drug test and post-offer physical (if required)
• Must be 18 years of age or older

Desired Experience, Skills and Abilities:

• Ph.D. in Analytical / Mass Spectrometry with strong background in Artificial Intelligence or similar area of study.

• Familiar with theory and fundamentals of mass spectrometry and ionization methodologies for small organic molecules.
• Experience in characterization of synthetic small organic molecules, natural products, or biomolecules by LC/MS.
• Strong background in theoretical and experimental organic chemistry to propose the origin of unknown components.
• A strong background in Python, C++, or equivalent platform for scientific computing as well as familiarity with general scientific data packages such as NumPy, SciPy, and pandas.
• Versed in modern coding practices for scientific computing, including algorithm design and evaluation, source code management and incorporation of readable documentation and comments.
• Expertise in computational approaches in at least one of the areas related to the research is required, including but not limited to Mass Spectrometry evaluation of metabolites, degradants and impurities, neural network design/ training/ evaluation, high speed computing, image analysis, large dataset analysis, error propagation and statistics.

• Excellent interpersonal oral and written communication skills; highly organized and efficient record keeping.
• Ability to provide clear reports and scientific direction to management, colleagues and collaborators.
• Experienced collaborating with diverse teams and demonstrated ability to work independently.
• Evidence of a publication record.

Boehringer Ingelheim is firmly committed to ensuring a safe, healthy, productive and efficient work environment for our employees, partners and customers.  As part of that commitment, Boehringer Ingelheim conducts pre-employment background investigations and drug screenings.  Boehringer Ingelheim is an equal opportunity employer. M/F/D/V

 

Contact:

Nina C. Gonnella, Ph.D.
Senior Associate Director
Material and Analytical Sciences
Boehringer Ingelheim Inc.
900 Ridgebury Rd.
Ridgefield, CT 06877
Office: 203-798-5518

nina.gonnella@boehringer-ingelheim.com

Boehringer Ingelheim is currently seeking a Mass Spectrometrist (Senior Scientist) to join the Material and Analytical Sciences department located at our Ridgefield, CT. facility. As an employee, you will actively contribute to the design, development and implementation of mass spectrometry and separation science technologies to solve challenging pharmaceutically related structural problems focusing on the structure elucidation and characterization of active pharmaceutical ingredients. Our global presence provides opportunity to collaborate internationally, offering visibility and the potential to directly contribute to the company's success. We realize that our strength and competitive advantage lie with our people. We support our employees and foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees.

 

Duties and Responsibilities:

• Responsible for developing, implementing and interpreting LC-MS based analytical methods (ESI/APCI MS, MS/MS and GC/MS) to solve complex analytical problems that advance the development of active pharmaceutical ingredients (APIs).

• Performs qualitative and quantitative GC-MS, LC-MS, and “wet” chemistry (isolation, extraction and derivatization).
• Explores innovative analytical technologies and emerging platforms to meet the needs of an evolving portfolio that may include novel molecular modalities and new therapeutic areas.
• Develops, tests and writes analytical methods and operating procedures based upon project requirements related to the characterization of molecules by LC/MS and GC/MS techniques .
• Supports work from cross-functional and international project teams and effectively manages the prioritization to meet multiple project goals and timelines.
• Conducts regular performance and preventive maintenance of laboratory instruments / equipment and performs troubleshooting of analytical test methods and laboratory instrumentation.
• Has the ability to detail experimental set-up, results and findings in an electronic notebook, perform expert analysis and interpretation of data and prepare well-written scientific reports.
• Complies with all safety and housekeeping practices based upon company policies and requirements.

Required Education and Experience:

• Ph.D. in Organic Chemistry, Biochemistry, or equivalent, with strong background in Mass Spectrometry and 1-3 years in the pharmaceutical industry. Candidates receiving Ph.D. in 2022 are also eligible to apply.

Eligibility Requirements:

• Must be legally authorized to work in the United States
• Must be willing to submit to a background investigation, including verification of your past employment, criminal history, and educational background
• Must be willing to take a drug test and post-offer physical (if required)
• Must be 18 years of age or older

Desired Experience Skills and Abilities:

• Ph.D. in Organic Chemistry, Biochemistry, or equivalent with strong background in mass spectrometry.
• Hands-on experience in the application of mass spectrometry and chromatographic techniques (LC/MS, GC/MS) for the analysis of APIs, degradants, impurities, metabolites, natural products, biopolymers etc.

• Strong background in theoretical and experimental organic chemistry to propose the origin of unknown components.

• Proven track record of successfully developing and applying LC-MS or LC-MS/MS methods to solve complex structural problems.
• Experience with mass spectrometry data collection and interpretation of oligonucleotides is highly desired.
• Hands on experience with MALDI (metabolites, peptides, proteins) or MALDI Imagining is a plus.
• Strong problem-solving ability in experimental design, execution, data interpretation and troubleshooting with limited supervision.
• Evidence of a scientific record through publications and presentations at professional conferences.
• Ability to work independently in a dynamic international team environment with cross-functional interactions.

• Excellent verbal and written communication skills and strong interpersonal skills.

 

Boehringer Ingelheim is firmly committed to ensuring a safe, healthy, productive and efficient work environment for our employees, partners and customers.  As part of that commitment, Boehringer Ingelheim conducts pre-employment background investigations and drug screenings.  Boehringer Ingelheim is an equal opportunity employer. M/F/D/V

 

Contact:

Nina C. Gonnella, Ph.D.
Senior Associate Director
Material and Analytical Sciences
Boehringer Ingelheim Inc.
900 Ridgebury Rd.
Ridgefield, CT 06877
Office: 203-798-5518
nina.gonnella@boehringer-ingelheim.com
or
scott.pennino@boehringer-ingelheim.com