Senior Technologist - High Resolution Mass Spectrometry

Job description: Under the guidance of the Lead Technologist, the Senior Technologist will apply their specialist technical knowledge and skills to assist academic staff, students and other stakeholders access the analytical platforms, primarily ESI/MALDI High resolution–Mass spectrometry, available in the Science Faculty’s Mass Spectrometry Facility.

Specialist Portfolio: Mass Spectrometry Facility

• Provide management and oversight of the Bruker solariX XR high-resolution ESI/MALDI FT-ICR mass spectrometer 

• Provide specialist training and advice to users, supporting the collection, interpretation, and management of complex data

• Provide expert input into research project planning

• Develop or adapt as required, sample preparation protocols, mass spectrometry methods and data analysis workflows

• Identify and implement relevant new techniques, workflows, and software packages

• Post-graduate research qualification in Biochemistry, Chemistry, Biology, Life Sciences or in a relevant field, and/or equivalent experience

• Experience: 4 to 5 years (post-graduation) including 1 to 2 years demonstrated experience in FT-MS analysis, in proteomics, MS-imaging, metabolomics or similar fields.

• FT-MS instrument maintenance, biological mass spectrometry, mass spectrometry data analysis, sample preparation techniques

• General laboratory skills (use of pipettes, centrifuges, balances etc)

• Intermediate Microsoft Office skills (Word, Excel and PowerPoint)

• Ability to effectively communicate complex mass spectrometry concepts and results to a broad community of users

The University of Auckland is New Zealand’s leading university and maintains significant computational, laboratory and analytic facilities. Auckland itself is frequently rated as one of the world’s most liveable cities. 

• Flexible employment practices (including working from home, flexible hours)

• Up to 6.75% company superannuation scheme

• A competitive salary with five weeks’ annual leave

Job description: Under the guidance of the Lead Technologist, the Senior Technologist will apply their specialist technical knowledge and skills to assist academic staff, students and other stakeholders access the analytical platforms, primarily ESI/MALDI High resolution–Mass spectrometry, available in the Science Faculty’s Mass Spectrometry Facility.

Knowledge and Skills

This position is a 36 month fixed term, fulltime role.

For more detailed information, please refer to the Position Description

Mō tō mātou rōpū | About the team

The Faculty of Science’s Technical Services Team comprises over 100 technical staff providing specialist support to the Faculty’s academic staff and students across 9 of the 10 Departments. They contribute technical knowledge and expertise to research and teaching activities while ensuring the ongoing operation and compliance of a vast range of laboratories, workshops, teaching facilities, research equipment, vehicles, and boats.

The Life Sciences Mass Spectrometry Platform (LSMS) is a cross-faculty initiative hosted by the Faculty of Science, Faculty of Medical and Health Sciences, and the Liggins Institute to promote access to cutting-edge mass spectrometry services and data analysis relevant to Life Sciences research. One component of the LSMS Platform is the Mass Spectrometry platform hosted in the Faculty of Science Shared Research Equipment programme.

The niche team are made up of specialist professionals and academics who work closely together on site.

Ngā āhuatanga kei a mātou | What we offer

The University is committed to providing an excellent working environment through:

In addition, we also offer career development programmes, discounted car parking, a generous parental leave allowance, childcare, and a number of other discounts on internal and external services. 

For more information, please visit Staff Benefits

Me pēhea te tuku tono | How to apply

Applications must be submitted online, by the closing date of 23 April 2022 to be considered. Please include your cover letter and your CV highlighting how you can meet the skills and experiences detailed above.

Please reach out to Martin Middleditch, Lead Technologist (Mass Spectometry) m.middleditch@auckland.ac.nz for a confidential conversation. Please note we are happy to answer your questions, but we do not accept applications by email.

Additional Information

Covid-19 Vaccination

The University of Auckland is committed to protecting the health, safety and well-being of our staff and students. All students, staff and visitors need to be fully vaccinated against Covid-19, or medically exempt, in order to come onto our campuses or to take part in face-to-face University-managed activities. Therefore, we are only able to consider applicants who are fully vaccinated against Covid-19 or have a New Zealand Ministry of Health issued medical exemption and evidence of this will be requested as part of your employment. You can read more about the University’s vaccination policy here.

Equity

The University is committed to meeting its obligations under the Treaty of Waitangi and achieving equity outcomes for staff and students in a safe, inclusive and equitable environment.  For further information on services for Māori, Pacific, women, LGBTQITakatāpui+, people with disabilities, parenting support, flexible work and other equity issues go to www.equity.auckland.ac.nz 

I'm interested

https://www.smartrecruiters.com/TheUniversityOfAuckland/743999814796456-senior-technologist-high-resolution-mass-spectrometry

School of Pharmacy, University of Southern California is seeking a core manager for mass spectrometry core.

The core manager will oversee and supervise day-to-day operations of a facility that broadly applies to metabolomics, lipidomics, proteomics, and MALDI imaging approaches to support basic, translational and clinical research in cancer, chronic inflammatory conditions, infectious diseases, neuroscience and pharmacological and biomarker development efforts. 

For detailed job description and apply: https://usccareers.usc.edu/job/los-angeles/core-manager-mass-spectrometry-core-facility/1209/19361658848.

Contact: 
Delisha Meishery-Patel, Ph.D.
delishap@usc.edu

Boehringer Ingelheim is currently seeking a Mass Spectrometry (Postdoctoral Associate) for program development to join the Material and Analytical Sciences department located at our Ridgefield, CT. facility.

As an employee, you will actively contribute to the design, development and implementation of novel Mass Spectrometry prediction programs for evaluating and advancing BI products. Our global presence provides opportunity to collaborate internationally, offering visibility and the potential to directly contribute to the company's success. We realize that our strength and competitive advantage lie with our people. We support our employees and foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees.

Duties and Responsibilities:

• Compile and analyze data of small organic molecules using Mass Spectrometry,
• Interpret EI, APCI and ESI MS and MS/MS fragmentation spectra.
• Mass Spectrometry identification of trace levels of small organic molecules that may result from process impurities, degradation products, or metabolites.
• Design and train neural networks to model components from Mass Spectrometry data.  This will involve curating training sets from experimental data.
• Assist in data collection and processing of Mass Spectrometry data as required.
• Document and manage code developed using standard source control methods.
• Research methods to scale training and use of neural networks on multiple nodes in high performance computing environments.
• Develop, document and maintain new and existing MS prediction software.
• Write protocols, methods and technical reports; provide scientific interpretation of results and maintain a detailed record of work performed.
• Contributing author to original manuscripts, posters and presentations; able to present work at external and internal scientific meetings.
• Independently solve complex problems with minimal assistance.

Required Education & Experience:

• Ph.D. in Analytical / Mass Spectrometry with strong background in Artificial Intelligence or similar area of study.

Eligibility Requirements:

• Must be legally authorized to work in the United States
• Must be willing to submit to a background investigation, including verification of your past employment, criminal history, and educational background
• Must be willing to take a drug test and post-offer physical (if required)
• Must be 18 years of age or older

Desired Experience, Skills and Abilities:

• Ph.D. in Analytical / Mass Spectrometry with strong background in Artificial Intelligence or similar area of study.

• Familiar with theory and fundamentals of mass spectrometry and ionization methodologies for small organic molecules.
• Experience in characterization of synthetic small organic molecules, natural products, or biomolecules by LC/MS.
• Strong background in theoretical and experimental organic chemistry to propose the origin of unknown components.
• A strong background in Python, C++, or equivalent platform for scientific computing as well as familiarity with general scientific data packages such as NumPy, SciPy, and pandas.
• Versed in modern coding practices for scientific computing, including algorithm design and evaluation, source code management and incorporation of readable documentation and comments.
• Expertise in computational approaches in at least one of the areas related to the research is required, including but not limited to Mass Spectrometry evaluation of metabolites, degradants and impurities, neural network design/ training/ evaluation, high speed computing, image analysis, large dataset analysis, error propagation and statistics.

• Excellent interpersonal oral and written communication skills; highly organized and efficient record keeping.
• Ability to provide clear reports and scientific direction to management, colleagues and collaborators.
• Experienced collaborating with diverse teams and demonstrated ability to work independently.
• Evidence of a publication record.

Boehringer Ingelheim is firmly committed to ensuring a safe, healthy, productive and efficient work environment for our employees, partners and customers.  As part of that commitment, Boehringer Ingelheim conducts pre-employment background investigations and drug screenings.  Boehringer Ingelheim is an equal opportunity employer. M/F/D/V

 

Contact:

Nina C. Gonnella, Ph.D.
Senior Associate Director
Material and Analytical Sciences
Boehringer Ingelheim Inc.
900 Ridgebury Rd.
Ridgefield, CT 06877
Office: 203-798-5518

nina.gonnella@boehringer-ingelheim.com

Boehringer Ingelheim is currently seeking a Mass Spectrometrist (Senior Scientist) to join the Material and Analytical Sciences department located at our Ridgefield, CT. facility. As an employee, you will actively contribute to the design, development and implementation of mass spectrometry and separation science technologies to solve challenging pharmaceutically related structural problems focusing on the structure elucidation and characterization of active pharmaceutical ingredients. Our global presence provides opportunity to collaborate internationally, offering visibility and the potential to directly contribute to the company's success. We realize that our strength and competitive advantage lie with our people. We support our employees and foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees.

 

Duties and Responsibilities:

• Responsible for developing, implementing and interpreting LC-MS based analytical methods (ESI/APCI MS, MS/MS and GC/MS) to solve complex analytical problems that advance the development of active pharmaceutical ingredients (APIs).

• Performs qualitative and quantitative GC-MS, LC-MS, and “wet” chemistry (isolation, extraction and derivatization).
• Explores innovative analytical technologies and emerging platforms to meet the needs of an evolving portfolio that may include novel molecular modalities and new therapeutic areas.
• Develops, tests and writes analytical methods and operating procedures based upon project requirements related to the characterization of molecules by LC/MS and GC/MS techniques .
• Supports work from cross-functional and international project teams and effectively manages the prioritization to meet multiple project goals and timelines.
• Conducts regular performance and preventive maintenance of laboratory instruments / equipment and performs troubleshooting of analytical test methods and laboratory instrumentation.
• Has the ability to detail experimental set-up, results and findings in an electronic notebook, perform expert analysis and interpretation of data and prepare well-written scientific reports.
• Complies with all safety and housekeeping practices based upon company policies and requirements.

Required Education and Experience:

• Ph.D. in Organic Chemistry, Biochemistry, or equivalent, with strong background in Mass Spectrometry and 1-3 years in the pharmaceutical industry. Candidates receiving Ph.D. in 2022 are also eligible to apply.

Eligibility Requirements:

• Must be legally authorized to work in the United States
• Must be willing to submit to a background investigation, including verification of your past employment, criminal history, and educational background
• Must be willing to take a drug test and post-offer physical (if required)
• Must be 18 years of age or older

Desired Experience Skills and Abilities:

• Ph.D. in Organic Chemistry, Biochemistry, or equivalent with strong background in mass spectrometry.
• Hands-on experience in the application of mass spectrometry and chromatographic techniques (LC/MS, GC/MS) for the analysis of APIs, degradants, impurities, metabolites, natural products, biopolymers etc.

• Strong background in theoretical and experimental organic chemistry to propose the origin of unknown components.

• Proven track record of successfully developing and applying LC-MS or LC-MS/MS methods to solve complex structural problems.
• Experience with mass spectrometry data collection and interpretation of oligonucleotides is highly desired.
• Hands on experience with MALDI (metabolites, peptides, proteins) or MALDI Imagining is a plus.
• Strong problem-solving ability in experimental design, execution, data interpretation and troubleshooting with limited supervision.
• Evidence of a scientific record through publications and presentations at professional conferences.
• Ability to work independently in a dynamic international team environment with cross-functional interactions.

• Excellent verbal and written communication skills and strong interpersonal skills.

 

Boehringer Ingelheim is firmly committed to ensuring a safe, healthy, productive and efficient work environment for our employees, partners and customers.  As part of that commitment, Boehringer Ingelheim conducts pre-employment background investigations and drug screenings.  Boehringer Ingelheim is an equal opportunity employer. M/F/D/V

 

Contact:

Nina C. Gonnella, Ph.D.
Senior Associate Director
Material and Analytical Sciences
Boehringer Ingelheim Inc.
900 Ridgebury Rd.
Ridgefield, CT 06877
Office: 203-798-5518
nina.gonnella@boehringer-ingelheim.com
or
scott.pennino@boehringer-ingelheim.com

Postdoctoral Research Fellow - Vanderbilt University: The laboratory of Jeff Spraggins in the Mass Spectrometry Research Center and Department of Cell & Developmental Biology at Vanderbilt University is looking for outstanding postdoctoral candidates that will join a team of graduate and post-graduate researchers to develop multimodal 2-D and 3-D imaging mass spectrometry. Multiple projects are available, including developing MALDI imaging instrumentation, spatially driven multi-omics, tissue processing and preparation methods, and computational data integration and mining tools. These projects involve constructing molecular atlases of human tissue and understanding the molecular drivers of host-pathogen interactions.

Post-doctoral candidates joining the Mass Spectrometry Research Center will have access to state-of-the-art instrumentation, including 9T and 15T Bruker Fourier transform ion cyclotron mass spectrometers with MALDI and ESI sources, two Bruker timsTOF ion mobility/Q-TOF mass spectrometers with MALDI and ESI capabilities, a Bruker Rapiflex MALDI tissuetyper, and a Thermo Orbitrap Elite mass spectrometer with a Spectroglyph transmission geometry source capable of 1 micron imaging. We also have high-performance LC-MS/MS instrumentation including a Thermo Orbitrap Fusion Tribrid mass spectrometer, a Bruker Impact II Q-TOF with a nanoElute LC system, and an Agilent AssayMAP Bravo liquid handler. Multimodal and microscopy-based imaging instrumentation include a GeoMX Digitial Spatial Profiler, a Zeiss Axio Observer Z1 inverted microscope integrated with an Akoya CODEX system, and a Zeiss Axio Scan Z1 brightfield and fluorescence slide scanner. The Mass Spectrometry Research Center also hosts a collection of commercial and state-of-the-art custom software for analysis of imaging, multiomics, and microscopy data.

Post-doctoral candidates will benefit from faculty with a diverse range of expertise including chemistry, biochemistry, engineering, computation, and biology. The Mass Spectrometry Research Center at Vanderbilt University is a leading institution for the development of imaging mass spectrometry and multimodal technologies providing a systems biology view of biological systems at cellular resolution.

Requirements: MALDI imaging, LC-MS, immunohistochemistry, and/or transcriptomics skills are required. Skills that are a plus, but not required, include instrumentation development, programming/scripting, bioinformatics, image processing and visualization, knowledge in pathology and infectious disease, ability to work simultaneously on multiple projects (including internal and external collaborations), and strong willingness to learn additional research skills if needed.

Location: Nashville, Tennessee, United States

Contact: If interested please email Jeff Spraggins at jeff.spraggins@vanderbilt.edu

Drug Metabolism and Distribution group within the DMPK department of Abbvie utilizes MS imaging to help drive molecules to the market. The successful candidate will pursue several research initiatives that will enhance the utility of MSI for tissue distribution and understanding of safety.  One area is to increase the sensitivity of imaging by utilizing novel ion source and targeted imaging methodologies to allow projects to be investigated when analytes fall below the current limit of detection. It is also important to Identify endogenous markers in various tissues (eye, liver, kidney, heart, etc.) to provide a high confidence of assignment in tissue distribution analysis. The generation of ion atlas will broadly improve spatial specificity, accelerate biomarker discovery for drug development, and significantly increase the ability to fully investigate the molecular drivers of biological processes. In addition, large molecule imaging methods and improved protocols need to be developed for MS imaging to be more robust and routine. This would permit the distribution of ADCs, antibody, and anticancer agents to be more fully investigated by MS imaging spectrometry.

please apply the position through Abbvie's site:

https://careers.abbvie.com/abbvie/jobs/2100676?lang=en-us&previousLocale=en-US

Investigator, MALDI MS Bioimaging (myworkdayjobs.com)

We have an exciting new position available within the MALDI MS Bioimaging group at GSK, based from our world-class R&D site at Collegeville, PA.  The role will focus on development of non-targeted imaging mass spectrometry-based workflows to deliver functional pharmacology mechanistic endpoints to projects.  As part of the MALDI MS Bioimaging team, you’ll be responsible for the application and advancement of imaging mass spectrometry (IMS) to better understand the mechanisms of drug tissue disposition, pharmacokinetics, pharmacology, and toxicology in the development of safe and efficacious drugs.  Utilizing leading edge MS instrumentation, custom imaging software tools, and pioneering IMS tissue quantification, our innovative group works collaboratively to help drive critical decisions in all therapeutic areas. 

Bioimaging at GSK

The Bioimaging department brings together key areas of in vivo and ex vivo imaging combined with histology to understand both disease state and intervention, combining data on drug distribution with the effect that distribution has on intact biological systems.  At GSK we believe that the fewer barriers there are in delivering the science, then the better our delivery of new medicines to patients. As part of the wider In Vitro/In Vivo Translation platform we encourage enterprise collaboration as well as external partnership with the wider scientific community to achieve our full potential.

Key Responsibilities:

• Develop non-targeted IMS workflows to deliver functional pharmacology mechanistic endpoints for projects and enhance understanding of biological systems

• Develop molecular identification strategies using tissue extracts and tissue surface analysis methods (e.g. LESA) to achieve accurate molecular assignment from MALDI imaging data

• Work in partnership with the Imaging Analytics teams and other stakeholders to build data repositories and custom pipelines to achieve streamlined identification of endogenous biological molecules and cellular pathways, and facilitate broader data reuse

• Work in partnership with project teams to understand project issues, provide input and report data to matrix teams, including close networking with all imaging groups across GSK.

• Maintain timely communication to named key study personnel, other key stakeholders and management, of study related events and/or deviations.

• Share responsibility for lab management, equipment maintenance, safety rep and similar roles.

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• PhD in Chemistry, Biology, Physical Sciences, or related discipline.

• Experience in mass spectrometry-based metabolomics and/or lipidomics data acquisition and analysis

• Familiarity and experience with common identification strategies for endogenous biological molecules

• Experience with troubleshooting and maintaining complex instrumentation

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• Expertise in imaging mass spectrometry

• Experience with Thermo or Bruker mass spectrometers

• Evidence of effective, collaborative interpersonal, organizational and communication skills, both oral and written, for working in a multi-disciplinary scientific team environment.

Why GSK?

Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:

• Operating at pace and agile decision-making – using evidence and applying judgement to balance pace, rigour and risk.

• Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.

• Continuously looking for opportunities to learn, build skills and share learning.

• Sustaining energy and well-being

• Building strong relationships and collaboration, honest and open conversations.

• Budgeting and cost-consciousness

*LI-GSK

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