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Postdoctoral Position - Developing and Applying Multimodal Molecular Imaging Technologies - USA

October 03, 2021 9:53 AM | Jeffrey Spraggins

Postdoctoral Research Fellow - Vanderbilt University: The laboratory of Jeff Spraggins in the Mass Spectrometry Research Center and Department of Cell & Developmental Biology at Vanderbilt University is looking for outstanding postdoctoral candidates that will join a team of graduate and post-graduate researchers to develop multimodal 2-D and 3-D imaging mass spectrometry. Multiple projects are available, including developing MALDI imaging instrumentation, spatially driven multi-omics, tissue processing and preparation methods, and computational data integration and mining tools. These projects involve constructing molecular atlases of human tissue and understanding the molecular drivers of host-pathogen interactions.

Post-doctoral candidates joining the Mass Spectrometry Research Center will have access to state-of-the-art instrumentation, including 9T and 15T Bruker Fourier transform ion cyclotron mass spectrometers with MALDI and ESI sources, two Bruker timsTOF ion mobility/Q-TOF mass spectrometers with MALDI and ESI capabilities, a Bruker Rapiflex MALDI tissuetyper, and a Thermo Orbitrap Elite mass spectrometer with a Spectroglyph transmission geometry source capable of 1 micron imaging. We also have high-performance LC-MS/MS instrumentation including a Thermo Orbitrap Fusion Tribrid mass spectrometer, a Bruker Impact II Q-TOF with a nanoElute LC system, and an Agilent AssayMAP Bravo liquid handler. Multimodal and microscopy-based imaging instrumentation include a GeoMX Digitial Spatial Profiler, a Zeiss Axio Observer Z1 inverted microscope integrated with an Akoya CODEX system, and a Zeiss Axio Scan Z1 brightfield and fluorescence slide scanner. The Mass Spectrometry Research Center also hosts a collection of commercial and state-of-the-art custom software for analysis of imaging, multiomics, and microscopy data.

Post-doctoral candidates will benefit from faculty with a diverse range of expertise including chemistry, biochemistry, engineering, computation, and biology. The Mass Spectrometry Research Center at Vanderbilt University is a leading institution for the development of imaging mass spectrometry and multimodal technologies providing a systems biology view of biological systems at cellular resolution.

Requirements: MALDI imaging, LC-MS, immunohistochemistry, and/or transcriptomics skills are required. Skills that are a plus, but not required, include instrumentation development, programming/scripting, bioinformatics, image processing and visualization, knowledge in pathology and infectious disease, ability to work simultaneously on multiple projects (including internal and external collaborations), and strong willingness to learn additional research skills if needed.

Location: Nashville, Tennessee, United States

Contact: If interested please email Jeff Spraggins at jeff.spraggins@vanderbilt.edu




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