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New Role at GSK - Investigator, Bioimaging

June 01, 2022 3:12 PM | Reid Groseclose

Investigator, Bioimaging (Collegeville, PA) (myworkdayjobs.com)

We have an exciting new position available within the Bioimaging team at GSK, based at our world-class R&D site in Collegeville, PA.  The role will focus on development of targeted and non-targeted optical and mass spectrometry-based imaging workflows to advance our project decision making based on spatial drug distribution and functional pharmacology mechanistic endpoints.  As part of the Bioimaging team, you’ll be responsible for the application and advancement of imaging mass spectrometry (IMS) to better understand the mechanisms of drug tissue disposition, pharmacokinetics, pharmacology, and toxicology in the development of safe and efficacious drugs.  Utilizing leading edge MS instrumentation, custom imaging software tools, and pioneering IMS tissue quantification, our innovative group works collaboratively to help drive critical decisions supporting the advancement of novel medicines.  Building on the established spatial drug distribution workflow, complementary imaging approaches are being applied to define the detailed tissue architectures and cellular microenvironments to contextualize the pharmacological outcome.  The successful candidate will join a highly collaborative and motivated team of scientists focused on providing innovative solutions to help deliver safe and efficacious new medicines to patients.

Bioimaging at GSK

The Bioimaging department brings together key areas of in vivo and ex vivo imaging combined with histology to understand both disease state and intervention, combining data on drug distribution with the effect that distribution has on intact biological systems.  At GSK we believe that the fewer barriers there are in delivering the science, then the better our delivery of new medicines to patients. As part of the wider In Vitro/In Vivo Translation platform we encourage enterprise collaboration as well as external partnership with the wider scientific community to achieve our full potential.

Key Responsibilities:

  • Responsible for the design, facilitation, and delivery of targeted and non-targeted MALDI IMS experiments including preparation, acquisition and data analysis to support multiple programs.
  • Responsible for generating and integrating spatial omics data to measure spatial biology, contextualize drug distribution, and discover pharmacodynamic biomarkers
  • Work together with matrix teams to propose and deliver potential solutions to key project issues including networking with other groups across GSK.
  • Effectively analyze and interpret IMS data for presentation to project teams.
  • Through collaboration with imaging and non-imaging colleagues, integrate IMS data with other methodologies as part of a multi-modal approach to drive critical project decisions.
  • Further the development of both quantitative and non-targeted IMS workflows to improve upon the impact and efficiency of acquisition and data processing strategies.
  • Support the upkeep and maintenance of lab instrumentation.

Basic qualifications:

  • PhD in Chemistry, Biology, Physical Sciences, or related discipline with a focus on the drug-discovery process.
  • Experience with generating spatial transcriptomics, proteomics, and/or metabolomics data.
  • Experience with troubleshooting and maintaining complex instrumentation.
  • Knowledge of visualization, statistics, and bioinformatic strategies.
  • Established track record of continued scientific contributions through presentations and publications.

Preferred Qualifications:

  • Hands-on experience with Bruker mass spectrometers including Solarix/SciMax and Rapiflex systems.
  • Evidence of effective, collaborative interpersonal, organizational and communication skills, both oral and written, for working in a multi-disciplinary scientific team environment.

Apply

Link to job posting:

Investigator, Bioimaging (Collegeville, PA) (myworkdayjobs.com)




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